*denotes corresponding authors
1denotes equally contributing first authors


A. Rehn1, J. Lawatscheck1, M.L. Jokisch, S.L. Mader, Q. Luo, F. Tippel, B. Blank, K. Richter, K. Lang, V.R.I. Kaila, J. Buchner*
A methylated lysine is a switch point for conformational communication in the chaperone Hsp90
NatComm, published online, doi: 10.1002/anie.201908209

Y.G. Mideksa1, M. Fottner, S. Braus, C.A.M. Weiß, T.A. Nguyen, S. Meier, K. Lang, M.J. Feige*
Site-Specific Protein Labeling with Fluorophores as a Tool To Monitor Protein Turnover
ChemBioChem, published online,



S.V. Mayer1, A. Murnauer1, M.K. von Wrisberg, M.L. Jokisch and K. Lang*
Photo-Induced and Rapid Labeling of Tetrazine-Bearing Proteins via Cyclopropenone-Caged Bicyclononynes.
Angew. Chem. Int Ed. 2019, published online, doi: 10.1002/anie.201908209

M. Reille-Seroussi, S.V. Mayer, W. Dörner, K. Lang and H.D.D. Mootz*
Expanding the Genetic Code with a Lysine Derivative Bearing an Enzymatically Removable Phenylacetyl Group
ChemComm 2019, published online, doi: 10.1039/C9CC00475K

A. Hohl*, Y.G. Mideksa, R. Karan, A. Akal, M. Vogler, M. Groll, M. Rueping, K. Lang, M.J. Feige, J. Eppinger*
Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells
Chembiochem 2019, published online, doi: 10.1002/cbic.201900015

M. Fottner, A-D. Brunner, V. Bittl, D. Horn-Ghetko, A. Jussupow, V.R.I. Kaila, A. Bremm and K. Lang*
Site-specific ubiquitylation and SUMOylation using genetic code expansion and sortase
Nat Chem Biology 2019, 15, 276

Highlighted as 'News and Views' article: Amit Kumar Singh Gautam and Andreas Matouschek: Decoding without the cipher
Nat Chem Biology 2019, 15, 210


T.A. Nguyen, M. Cigler, K. Lang*,
Expanding the Genetic Code to Study Protein–Protein Interactions,
Angew. Chem. Int. Ed. 2018, published online, doi; 10.1002/anie-201805869

M. Cigler, T.A. Nguyen and K. Lang*,
Genetic code expansion approaches to introduce artificial covalent bonds into proteins in vivo.
In M.J. Feige (Ed), Oxidative Folding of Proteins, 2018, RSC Publishing

K. Lang*,
Building Peptide Bonds in Haifa: The Seventh Chemical Protein Synthesis (CPS) Meeting.
2018, 19, 115-120 (Conference Report)


M. Cigler1, T.G. Müller1, D. Horn-Ghetko, M.K. von Wrisberg, M. Fottner, R. S. Goody, A. Itzen, M.P. Müller and K. Lang*,
Proximity-triggered covalent stabilization of low affinity protein complexes in vitro and in vivo.
Angew. Chem. Int. Ed. 2017, doi: 10.1002/anie.201706927
recommended by F1000Prime as being of special significance in its field

S. Mayer and K. Lang*,
Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology
Synthesis 2017, 49, 830

S. Mayer and K. Lang*,
Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology
Synthesis 2017, 49, 830


L. Jiao* and K. Lang*,
The 6th Sino-German Frontiers of Chemistry Symposium.
Chem Asian J.
2016, 11, 3292 (Invited Conference Report)

S. Mayer and K. Lang*,
Chemie in lebenden Systemen
Nachrichten aus der Chemie 2017, 64 (3), 301-305 (Invited Report)


T. Yu-Hsuan, S. Essig, J. James, K. Lang, and J.W. Chin*
Selective, rapid and optically switchable regulation of protein function in live mammalian cells
Nat. Chem. 2015, 7, 554. 

T. Machida, K. Lang, L. Xue, J.W. Chin and N. Winssinger*
Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne
Bionconjug. Chem. 2015, 26, 802.

C. Uttamapinant, J.D. Howe, K. Lang, V. Beranek, L. Davis, M. Mahesh, N.P. Barry* and J.W. Chin*
Genetic code expansion enables live-cell and super-resolution of site-specifically labelled cellular proteins
J. Am. Chem. Soc 2015, 137, 4602.

K. Lang*, L. Davis* and J.W. Chin
Genetic Encoding of Unnatural Amino Acids for Labeling Proteins
Methods Mol. Biol. 2015, 1266, 217.


K. Wang, A. Sachdeva, D.J. Cox, N.W. Wilf, K. Lang, S. Wallace, R.A. Mehl and J.W. Chin*
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double labelling and FRET
Nat. Chem. 2014, 6, 393. 

T.S Elliott, F.M. Townsley, A. Bianco, R.J. Ernst, A. Sachdeva, S.J. Elsässer, L. Davis, K. Lang, R. Pisa, S. Greiss, K.S. Lilley and J.W. Chin*
Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
Nat. Biotechnol. 2014, 32, 465.

K. Lang*, J.W. Chin*
Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
Chem. Rev. 2014, 114, 4764.

D. Perez-Fernandez, D. Shcherbakov, T. Matt, N.C. Leong, I. Kudyba, S. Duscha, H. Boukari, R. Patak, S.R. Dubbaka, K. Lang, M. Meyer, R. Akbergenov, P. Freihofer, S. Vaddi, P. Thommes, V. Ramakrishnan, A. Vasella, E.C. Böttger
4'-O-substitutions determine selectivity of aminoglycoside antibiotics
Nat. Commun. 2014, 5:3112, doi: 10.1038/ncomms4112.

K. Lang*, J.W. Chin*
Bioorthogonal reactions for labeling proteins
ACS Chem. Biol. 2014, 9, 16.


K. Lang* and J.W. Chin*
Fluorescence imaging: shining a light into live cells
Nat. Chem. 2013, 5, 81. 


A. Bianco, F. Townsley, S. Greiss, K. Lang, and J.W. Chin*
Expanding the genetic code of drosophila melanogaster
Nat. Chem. Biol. 2012, 8, 748.

T. Matt1, C.L. Ng1, K. Lang1, S.H. Sha1, R. Akbergenov1, D. Shcherbakov1, M. Meyer, S. Duscha, J. Xie, S.R. Dubbaka, D. Perez-Fernandez, A. Vasella, V. Ramakrishnan, J. Schacht, E.C. Böttger*
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
PNAS 2012, 109, 10984.

K. Lang, L. Davis, S. Wallace, M. Mahesh, D.J. Cox, M.L. Blackman, J.M. Fox, J.W. Chin*
Genetic encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions
J. Am. Chem. Soc. 2012, 134, 10317.

K. Lang1, L. Davis1, J. Torres-Kolbus, C. Chou, A. Deiters*, J.W. Chin*
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
Nat. Chem. 2012, 5, 298.


S. Virdee, P.B. Kapadnis, T. Elliott, K. Lang, J. Madrzak, D.P. Nguyen, L. Riechmann, J.W. Chin*
Traceless and site-specific ubiquitination of recombinant proteins
J. Am. Chem. Soc. 2011, 133, 10708. 


L. Ng1, K. Lang1, N. Meenan, A. Sharma, A. Kelley, C. Kleanthous*, V. Ramakrishnan*
Structural basis for ribosomal 16S rRNA cleavage by the cytotoxic domain of colicin E3
Nat. Struct. Mol. Biol. 2010, 17, 1241.


U. Rieder, K. Lang, C. Kreutz, N. Polacek, R. Micura*
Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers
ChemBioChem 2009, 10, 1141. 

V. Olieric, U. Rieder, K. Lang, A. Serganov, C. Schulze-Briese, R. Micura, P. Dumas, E. Ennifar*
A fast selenium derivatization strategy for crystallization and phasing of RNA structures
RNA 2009, 15, 707.


K. Lang and R. Micura*
The preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized RNA fragments
Nat. Protocols 2008, 3, 1457. 

K. Lang, M.D. Erlacher, D.N. Wilson, R. Micura* and N. Polacek*
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis
Chemistry & Biology 2008, 15, 485.

S. Freisz, K. Lang, R. Micura, P. Dumas and E. Ennifar*
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA Dimerization Initiation Site
Angew. Chem. Int. Ed. Engl. 2008, 47, 4110.


 K. Lang, R. Rieder, and R. Micura*
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach
Nucleic Acids Research 2007, 35, 5370.

R. Rieder, K. Lang, D. Graber, and R. Micura*
Ligand-induced folding of the adenosine deaminase A-riboswitch and implications on riboswitch translational control
ChemBioChem 2007, 8, 896.


M.D. Erlacher, K. Lang, B. Wotzel, R. Rieder, R. Micura* and N. Polacek*
Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2’-OH at A2451 of 23S rRNA
J. Am. Chem. Soc. 2006, 128, 4453. 

H. Moroder, C. Kreutz, K. Lang, A. Serganov, and R. Micura*
Synthesis, oxidation behavior, crystallization and structure of 2’-methylseleno guanosine containing RNAs
J. Am. Chem. Soc. 2006, 128, 9909.

R. Micura, C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, H. Moroder
Preparation of 2’-deoxy-2’-methylseleno-modified RNA
Current Protocols in Nucleic Acid Chemistry 2006, Wiley, C1.15.1 – C1.15.34.


M.D. Erlacher, K. Lang, N. Shankaran, B. Wotzel, A. Hüttenhofer, R. Micura, A.S. Mankin and N. Polacek*
Chemical engineering of the peptidyl transferase center reveals an important role of the 2’-hydroxyl group of A2451
Nucleic Acids Research 2005, 33, 1618. 

C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, A. Polonskaia, A. Serganov, and R. Micura*
Syntheses of RNAs with up to 100 nucleotides containing site-specific 2’-Se-methyl labels for use in X-ray crystallography
J. Am. Chem. Soc. 2005, 127, 12035.