Publications

Google Scholar profile of Stephan M. Hacker

2020

K. Bach,* B. Beerkens,* P. R. A. Zanon,* S. M. Hacker,# " Light-activatable, 2,5-disubstituted tetrazoles for the proteome-wide profiling of aspartates and glutamates in living bacteria”, ACS Cent. Sci., doi.

P. R. A. Zanon, L. Lewald, S. M. Hacker,# “Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome“, Angew. Chem. Int. Ed. 2020, 59, 2829-2836, doi.

K. M. Lee, P. Le, S. A. Sieber,# S. M. Hacker,# “Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines“, Chem. Commun. 2020, 56, 2929-2932, doi.

P. Le,* E. Kunold,* R. Macsics,* K. Rox, M. C. Jennings, I. Ugur, M. Reinecke, D. Chaves-Moreno, M. W. Hackl, C. Fetzer, F. A. M. Mandl, J. Lehmann, V. S. Korotkov, S. M. Hacker, B. Kuster, I. Antes, D. H. Pieper, M. Rohde, W. M. Wuest, E. Medina, S. A. Sieber,# “Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms”, Nat. Chem. 2020, 12, 145-158, doi.

2019

C. M.-L. Gleissner,* C. L. Pyka,* W. Heydenreuter,* T. F. Gronauer, C. Atzberger, V. S. Korotkov, W. Cheng, S. M. Hacker, A. M. Vollmar, S. Braig,# S. A. Sieber,# “Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways“, ACS Cent. Sci. 2019, 5, 1170-1178, doi

2017

S. M. Hacker,#,* K. M. Backus,#,* M. Lazear, S. Forli, B. Correia, B. F. Cravatt,# “Global profiling of lysine reactivity and ligandability in the human proteome“, Nat. Chem. 2017, 9, 1181-1190, doi.

S. Ermert, A. Marx, S. M. Hacker,# “Phosphate-Modified Nucleotides for Monitoring Enzyme Activity”, in: H. Jessen (Editor) “Topics in Current Chemistry: Phosphate Labeling in Chemical Biology”, 2017, 375, 28, doi.

S. Ermert, S. M. Hacker, A. Buntru, M. Scheffner, C. R. Hauck, A Marx,# “Different Enzymatic Processing of γ-Phosphoramidate and γ-Phosphoester-modified ATP Analogs”, ChemBioChem 2017, 18, 378-381, doi.

K. H. Götz, S. M. Hacker, D. Mayer, J.-N. Dürig, S. Stenger, A. Marx,# “Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis”, ACS Chem. Biol. 2017, 12, 2682-2689, doi.

S. Lange, S. M. Hacker, P. Schmid, M. Scheffner, A. Marx,# "Small-Molecule Inhibitors of the Tumor Suppressor Fhit", ChemBioChem 2017, 18, 1707-1711, doi.

2015

S. M. Hacker, A. Buntz, A. Zumbusch,# A. Marx,# “Direct Monitoring of Nucleotide Turnover in Human Cell Extracts and Cells by Fluorogenic ATP Analogs”, ACS Chem. Biol. 2015, 10, 2544-2552, doi.

S. M. Hacker,# M. Welter, A. Marx,# “Synthesis of γ-Phosphate Labelled and Doubly Labelled Adenosine Triphosphate Analogs”, Curr. Prot. Nucl. Acid Chem. 2015, 60, 13.14.1-13.14.25, doi.

2014

S. M. Hacker, F. Mortensen, M. Scheffner, A. Marx,# “Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit”, Angew. Chem. Int. Ed. 2014, 53, 10247-10250, doi.

S. M. Hacker,#,* C. Hintze,* A. Marx,# M. Drescher,# “Monitoring Enzymatic ATP Hydrolysis by EPR Spectroscopy“, Chem. Comm. 2014, 50, 7262-7264, doi.

O. B. Gutiérrez Acosta,* N. Hardt,* S. M. Hacker, T. Strittmatter, B. Schink,# A. Marx,# “Thiamine Pyrophosphate Stimulates Acetone Activation by Desulfococcus biacutus As Monitored by a Fluorogenic ATP Analogue”, ACS Chem. Biol. 2014, 9, 1263-1266, doi.

2013

S. M. Hacker, D. Pagliarini, T. Tischer, N. Hardt, D. Schneider, M. Mex, T. U. Mayer, M. Scheffner,# A. Marx,# “Novel Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real-Time”, Angew. Chem. Int. Ed. 2013, 52, 11916-11919, doi.

S. M. Hacker,* N. Hardt,* A. Buntru, D. Pagliarini, M. Möckel, T. U. Mayer, M. Scheffner, C. R. Hauck, A. Marx,# “Fingerprinting Differential Active Site Constraints of ATPases”, Chem. Sci. 2013, 4, 1588-1596, doi.

N. Hardt,* S. M. Hacker,* A. Marx,# “Synthesis and Fluorescence Characteristics of ATP-based FRET Probes”, Org. Biomol. Chem. 2013, 11, 8298-8305, doi.

2012

S. M. Hacker, M. Mex, A. Marx,# “Synthesis and Stability of Phosphate Modified ATP Analogues”, J. Org. Chem. 2012, 77, 10450-10454, doi.

 

 

# corresponding author(s), * these authors contributed equally to this work