Doktoranden

Bauer, Elisabeth

M. Sc., Doktorandin (seit Juli 2016)
(Medicinal Chemistry)

Raum: CRC 4007
Tel.: (089) 289 54112
E-Mail: elisabeth.bauer@tum.de

Bernd, Marco

M. Sc., Doktorand (Seit November 2017
(Medicinal Chemistry)

Raum: CRC 2012
Tel.: (089) 289 54204
E-Mail: marco.bernd@tum.de

Dominelli, Bruno

M. Sc., Doktorand (Seit November 2016)
(Medicinal Chemistry)

Raum: CRC 4008
Tel.: (089) 289 54113
E-Mail: bruno.dominelli@tum.de

My research focuses on the synthesis of dinuclear gold(I) complexes bearing bidentate NHC ligand moieties (NHC = N-heterocyclic carbene). This ligand system offers different functional groups on the bridge and varied N-substituents with the target to equilibrate the degree of lipo- and hydrophilicity of the resulting complexes for medicinal purposes. Additionally, the functional groups allow the coupling to bio-relevant compounds to enable selectivity and detection studies. The focus is set on in vitro anti-cancer studies.

References:
[1] J. Rieb, B. Dominelli, D. Mayer, C. Jandl, J. Drechsel, W. Heydenreuter, S. A. Sieber, F. E. Kühn Dalton Trans. 2017, 46, 2722-2735.
[2] B. Dominelli, J. D. G. Correia, F. E. Kühn J. Organomet. Chem. 2018, 886, 153-164.

Dyckhoff, Florian

M. Sc., Doktorand (Seit Oktober 2017)
(Iron-NHC Complexes in Catalysis)

Raum: 56422
Tel.: (089) 289 13586
E-Mail: florian.dyckhoff@tum.de

My research targets the evaluation of transition metal complexes with regard to their applicability in oxidation catalysis. In industry, cheap and efficient catalysts for e.g. epoxidation reactions or C-H activation are indispensible to convert semi-finished goods like alkanes and olefins into valuable products. Additionally to the testing of possibly applicable catalysts, my focus lies on the synthesis of functionalized tetradentate NHC ligand systems with the ultimate goal to graft the respective metal complexes onto solid support.

List of publications:
[1] F. Dyckhoff, S. Li, R. M. Reich, B. J. Hofmann, E. Herdtweck, F. E. Kühn, Dalton Trans. 2018, 47, 9755-9764.
[2] F. Dyckhoff, F. Kaiser, S. Hölzl, F. E. Kühn, Z. anorg. allg. Chem. 2019, 645, 207-211.

Egger, Christiane

M. Sc., Doktorandin (seit Juli 2016)
(BMBF Project)

Raum: CRC 2010
Tel.: (089) 289 54203
E-Mail: christiane.egger@mytum.de

Esslinger, Eva

M. Sc., Doktorandin (seit September 2018)
(Industrial Project)

Raum: CRC 4008
Tel.: (089) 289 54113
E-Mail: eva.esslinger@tum.de

Fischer, Pauline

M. Sc., Doktorandin (seit Dez. 2015)
(Ionic Liquids)

Raum: CRC 4008
Tel.: (089) 289 54113
E-Mail: pauline.fischer@tum.de

Han, Li

M. Sc., Doktorand (seit Oktober 2015)
(Photocatalysis)

Raum: CRC 4008
Tel.: (089) 289 54113
E-Mail: ga89lab@mytum.de

Hey, Daniela

M. Sc., Doktorandin (seit Dezember 2017)
(Ruthenium Complexes for Hydrogenation Catalysis)

Raum: CRC 2011
Tel.: (089) 289 54204
E-Mail: daniela.hey@tum.de

Ruthenium(II) phosphine complexes with appropriate ancillary ligands are known as highly active catalysts in hydrogenation reactions, for example in the transfer hydrogenation of ketones. Starting from Ru(OAc)2(PPh3)2, my aim is to tune the ligands in a way to create particularly active, but at the same time highly robust catalysts. Examined systems include trifluoroacetate, acetylacetonate, and N-heterocyclic carbene complexes.

References:
D. A. Hey, R. M. Reich, W. Baratta, F. E. Kühn, Coord. Chem. Rev. 2018, 374, 114-132.

Hinterberger, Andreas

M. Sc., Doktorand (seit Februar 2017)
(Industrial Project)

Raum: CRC 4006
Tel.: (089) 289 54111
E-Mail: andreas.hinterberger@tum.de

Hofmann, Benjamin

M. Sc., Doktorand (seit Juli 2016)
(Wacker Project)

Raum: 56422
Tel.: (089) 289 13586
Tel2.: (089) 289 13582 (Dunkellabor)
E-Mail: ben.hofmann@tum.de

List of Publication:

[1] R. Zhong, A. Pöthig, S. Haslinger, B. Hofmann, G. Raudaschl-Sieber, E. Herdtweck, W.A. Herrmann, F.E. Kühn, ChemPlusChem, 79 (2014) 1294-1303.
[2] S.A. Reindl, A. Pöthig, B. Hofmann, W.A. Herrmann, F.E. Kühn, Journal of Organometallic Chemistry, 775 (2015) 130-136.
[3] J.W. Kück, M.R. Anneser, B. Hofmann, A. Pöthig, M. Cokoja, F.E. Kühn, ChemSusChem, 8 (2015) 4056-4063.
[4] Z.S. Ghavami, M.R. Anneser, F. Kaiser, P.J. Altmann, B.J. Hofmann, J.F. Schlagintweit, G. Grivani, F.E. Kühn, Chemical Science, 9 (2018) 8307-8314.
[5] F. Dyckhoff, S. Li, R.M. Reich, B.J. Hofmann, E. Herdtweck, F.E. Kühn, Dalton Transactions, 47 (2018) 9755-9764.
[6] B.J. Hofmann, S. Huber, R.M. Reich, M. Drees, F.E. Kühn, Journal of Organometallic Chemistry, 885 (2019) 32-38.
[7] B.J. Hofmann, R.G. Harms, S.P. Schwaminger, R.M. Reich, F.E. Kühn, Journal of Catalysis, 373 (2019) 190-200.

Hölzl, Sebastian

M. Sc., Doktorand (seit Sept. 2016)
(Wacker Project)

Raum: CRC 2010
Tel.: (089) 289 54203
E-Mail: sebastian.hoelzl@tum.de

Jakob, Christian

M. Sc., Doktorand (seit Dezember 2017)
(Medicinal Chemistry)

Raum: CRC 4008
Tel.: (089) 289 54113
E-Mail: christian.jakob@tum.de

My research focusses on the utilization of histidine as a suitable precursor for gold(I) NHC complexes (NHC = N-heterocyclic carbene). This ligand system offers an amino acid functionality in the backbone, which allows the coupling of bio-relevant compounds to increase the selectivity towards tumor cells (e.g. integrine ligands). The focus is set on in vitro anti-cancer studies.

Jikun, Yang

M. Sc., Doktorand (seit Oktober 2017)
(KAUST Project)

Raum: CRC 4006
Tel.: (089) 289 54111
E-Mail: jikun.yang@tum.de

Ludwig, Stefanie Beatrice

M. Sc., Doktorandin (seit Februar 2018)
(Medicinal Chemistry)

Raum: CH32405
E-Mail: steffi.ludwig@tum.de

Basis for the development, the preservation and the function of all cell and tissue types in multicellular organisms is the adhesion of cells among themselves as well as to the surrounding extracellular matrix. These interactions between the extracellular environment of a cell and the cytoskeleton inside the cell are mediated by cell adhesion receptors, as through the large group of integrins. Many tumor types overexpress integrins, as well. My research focuses on the synthesis of selective as well as high affine integrin ligands, the conjugation of these with cytotoxic, fluorescent and/or radioactive molecules and their study in in vitro as well as in in vivo experiments. Thus, I want to generate not only suitable conjugates for diagnostic or interoperative imaging and therapeutic purposes, but also understand, how signaling pathways inside cancer cells are affected by especially cytotoxic integrin ligand conjugates.

Oberkofler, Jens

M. Sc., Doktorand (seit August 2017)
(Medicinal Chemistry)

Raum: CRC 4007
Tel.: (089) 289 54112
E-Mail: jens.oberkofler@tum.de

My research focuses on the synthesis of mixed Au(I) organometallics and their potential as anticancer drugs. We recently demonstrated that an NHC-Au(I)-alkynyl complex is highly cytotoxic in cancer cells in vitro, while being scarcely toxic in healthy rat kidney tissues ex vivo. Following these promising results, a systematic study is being conducted to get a basic understanding of the reactivity and mechanisms of action of this family of mixed organometallic compounds.

References:
[1] B. Bertrand, A. Casini, Dalton Trans. 2014, 43, 4209-4219.
[2] N. Estrada-Ortiz, F. Guarra, I. A. M. de Graaf, L. Marchetti, M. H. de Jager, G. M. M. Groothuis, C. Gabbiani, A. Casini, ChemMedChem, 2017, 12, 1429-1435.

Obermayer, Carolin

M. Sc., Doktorandin (seit Februar 2017)
(Iron-NHC Complexes in Catalysis)

Raum: CRC 4007
Tel.: (089) 289 54112
E-Mail: carolin.obermayer@mytum.de

Iron is one of the most abundant elements on earth playing an important role in many different biological processes. Many examples depict the diversity of these processes, e.g. the oxygen transport in the blood and the oxidation of non-activated hydrocarbons. My research focuses on the synthesis of artificial heme analogue systems and the modification of cyclic NHC (=N-heterocyclic carbene) ligands for catalytic purpose.

References:
[1] M. R. Anneser, S. Haslinger, A. Pöthig, M. Cokoja, J.-M. Basset, F. E. Kühn, Inorganic Chemistry 2015, 54, 3797-3804.
[2] K. Riener, S. Haslinger, A. Raba, M. P. Högerl, M. Cokoja, W. A. Herrmann, F. E. Kühn, Chemical Reviews 2014, 114, 5215-5272.

Pardatscher, Lorenz

M. Sc., Doktorand (seit Dezember 2016)
(Hydration/Hydrogenation Catalysis)

Raum: CRC 2010
Tel.: (089) 289 54203
E-Mail: lorenz.pardatscher@tum.de

Schlagintweit, Jonas

M. Sc., Doktorand (seit Februar 2018)
(Iron-NHC Complexes in Catalysis)

Raum: CRC 4006
Tel.: (089) 289 54111
E-Mail: jonas.schlagintweit@tum.de

Tappe, Nadine

M. Sc., Doktorandin (seit Januar 2017)
(Iron-NHC Complexes in Catalysis)

Raum: CRC 2010
Tel.: (089) 289 54203
E-Mail: nadine.tappe@tum.de

Xu, Dawen

M. Sc., Doktorand (seit November 2016)
(Photocatalysis)

Raum: CRC 2005
Tel: (089) 289 54200
E-Mail: dawen.xu@tum.de

My research focusses on the reaction of intramolecular diene under thermo- or photo- conditions. The reaction of intramolecular diene offers great opportunity to generate cyclized rings which is useful for the synthesis of bioactive compounds.

Reference:
[1] Dawen Xu, Felix Kaiser, Han Li, Hao Guo, Fritz E. Kühn, Highly selective AlCl3 initiated intramolecular α-alkylation of α,β-unsaturated lactams and lactones, Chem. Commun., under revision.