Insight into the genesis and the various treatments of tumours and infections. The mechanism and clinical applications of various cytostatics, antibiotics, antivirals and antiprotozoals will be discussed during the course. It will always tie in with the chemical structure, pharmacokinetic properties, side effects and possible resistance of different drugs. Main classes of protein drug target and their biological roles, and then illustrate these with specific target/drug examples drawn from different disease areas. Non-protein drug targets will also be discussed, highlighting membranes and nucleic acids as targets for anticancer, antiviral, antiprotozoal and antibiotic compounds. Students will gain an appreciation of areas of unmet clinical need, novel drug targets and current trends. Moreover, lectures of CADD (computer-aided drug discovery), including 3D-QSAR modeling, machine learning in drug design, ligand-based (LB) virtual screening, fragment-based drug discovery and molecular dynamics (MD) will also be included.
Advanced knowledge of organometallic chemistry and its applications. Overview of the reaction behavior of different families of organometallic compounds including: design and synthesis of organometallics, reaction mechanisms in organometallic chemistry, current problems on the research front of organometallic chemistry, modern applications of organometallics in catalysis research, modern applications of organometallics in materials science, novel applications in medicinal chemistry and chemical biology. In all subject areas, the focus is on the detailed understanding of the molecular and mechanistic aspects and the interaction and inerplay of organometallic compounds with their reaction partners or their chemical environment.
After completing this module, students will be able to categorize inorganic substances and understand and classify chemical reactions. The students have acquired basic knowledge of the chemistry of the elements and are able to transfer these to new tasks. In addition, students have a broad knowledge of inorganic materials and their properties.