Publications in Scientific Journals

1 equal contribution
* correspondence

2023

Höpfner D, Cichy A, Pogenberg V, Krisp C, Mezouar S, Bach NC, Grotheer J, Zarza SM, Martinez E, Bonazzi M, Feige MJ, Sieber SA, Schlüter H, Itzen A*
The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii fic enzyme targets histone H3. [read]
Commun Biol, 6:1124.

Hildenbrand K1, Bohnacker S1, Menon PR, Kerle A, Prodjinotho UF, Hartung F, Strasser PC, Catici DAM, Rührnößl F, Haslbeck M, Schumann K, Müller SI, da Costa CP, Esser-von Bieren J, Feige MJ*
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions. [read]
Science Advances, 9:43.

Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, Rührnößl F, Catici D, Haslbeck M, Frishman D, Sattler M, Zacharias M, Feige MJ*
Assembly-dependent structure formation shapes human interleukin-23 versus interleukin-12 secretion. [read]
J Mol Biol, 435(23):168300.

Liebl K1, Aschenbrenner I1, Schiller L1, Kerle A1, Protzer U*, Feige MJ*
Modeling of the human interleukin 12:receptor complex allows to engineer attenuated cytokine variants. [read]
Mol Immunol, 162:38-44.

Muñoz AW, Meighen-Berger KM, Hacker SM, Feige MJ, Sieber SA*
A chemical probe unravels the reactive proteome of health-associated catechols. [read]
Chem Sci, 14(32):8635-8643.

Pradhan T, Sarkar R, Meighen-Berger KM, Feige MJ, Zacharias M, Reif B*
Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005. [read]
Nat Commun, 14(1):3755.

 

2022

Blömeke N, Meighen-Berger K, Hitzenberger M, Bach NC, Parr M, Coelho JPL, Frishman D, Zacharias M, Sieber SA, Feige MJ*

Intra-membrane client recognition potentiates the chaperone functions of Calnexin. [read]

EMBO J, 15;41(24):e110959.

 

Zanotti A1, Coelho JPL1, Kaylani D, Singh G, Tauber M, Hitzenberger M, Avci D, Zacharias M, Russel RB, Lemberg MK*, Feige MJ*

The human signal peptidase complex acts as a quality control enzyme for membrane proteins. [read][press release]

Science, 378(6623):996-1000.

 

Mideksa YG1, Aschenbrenner I1, Fux A, Kaylani D, Weiß CAM, Nguyen TA, Bach NC, Lang K, Sieber SA, Feige MJ*

A comprehensive set of ER protein disulfide isomerase family memberssupports the biogenesis of pro-inflammatory interleukin 12 family cytokines. [read]

J Biol Chem, 298(12):102677.

 

Hildenbrand K1, Aschenbrenner I1, Franke FC1, Devergne O*, Feige MJ*

Biogenesis and engineering of interleukin 12 family cytokines. [read]
TIBS, 47(11):936-949.

2021

Kong KYE, Coelho JPL, Feige MJ, Khmelinskii A*

Quality control of mislocalized and orphan proteins. [read]
Exp Cell Res, 403(2):112617.

 

Min B*, Kim D, Feige MJ

IL-30 (IL-27A): a familiar stranger in immunity, inflammation, and cancer. [read]
Exp Mol Med, 53(5):823-834.

 

Fauser J, Gulen B, Pogenberg V, Pett C, Pourjafar-Dehkordi D, Krisp C, Höpfner D, König G, Schlüter H, Feige MJ, Zacharias M, Hedberg C*, Itzen A*

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD. [read]
Nat Commun, 12(1):2426.

 

Schlagintweit JF1, Jakob CHG1, Meighen-Berger K, Gronauer TF, Weigert Muñoz A, Weiß V, Feige MJ, Sieber SA, Correia JDG, Kühn FE*

Fluorescent palladium(II) and platinum(II) NHC/1,2,3-triazole complexes: antiproliferative activity and selectivity against cancer cells. [read]
Dalton Trans, 50(6):2158-2166.

 

2020

Bohnacker S1, Hildenbrand K1, Aschenbrenner I1, Müller SI, Esser-von Bieren J*, Feige MJ*
Influence of glycosylation on IL-12 family cytokine biogenesis and function. [read]
Mol Immunol, 126:120-128.

Cave MC, Maillard S, Hildenbrand K, Mamelonet C, Feige MJ, Devergne O*
Glycosaminoglycans bind human IL-27 and regulate its activity. [read]
Eur J Immunol, 50(10):1484-1499.

Mideksa YG, Fottner M, Braus S, Weiß CAM, Nguyen TA, Meier S, Lang K, Feige MJ*
Site-specific protein labeling with fluorophores as a tool to monitor protein turnover. [read]
ChemBioChem, 21(13):1861-1867.

Coelho JPL, Feige MJ*
In case of stress, hold tight: phosphorylation switches PDI from an oxidoreductase to a holdase, tuning ER proteostasis. [read]
EMBO J, 39(10).

de los Reyes Jimenez M1, Lechner A1, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourao A, Geerlof A, Prazeres de Costa C, Chaker AM, Brüne B, Nüssing R, Jakobsson, PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J*
An anti-inflammatory eicosanoid switch mediates the suppresion of type-2 inflammation by helminth larval products. [read]
Science Translational Medicine, 12(540).

Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler S, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A*, Reif B*
Structural insights into IAPP-derived amyloid inhibitors and their mechanism of action. [read]
Angewandte Chemie, 59(14):5771-5781.

2019

Hennig J*, Feige MJ*
Highlight: Young research groups in Germany - continued. [read]
Biol Chem, 400(11):1395.

 

Meier S, Bohnacker S, Klose CJ, Lopez A, Choe CA, Schmid PWN, Bloemeke N, Rührnößl F, Haslbeck M, Esser-von Bieren J, Sattler M, Huang PS, Feige MJ*

The molecular basis of chaperone-mediated interleukin 23 assembly control. [read] , [press release]
Nat Commun, 10:4121.

 

Hohl A*, Mideksa YG, Akal A, Karan R, Vogler M, Groll M, Rueping M, Lang K, Feige MJ, Eppinger J*
Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells. [read]
ChemBioChem, 20(14):1795-1798.

 

Hennig J*, Feige MJ*
Highlight: Young research groups in Germany. [read]
Biol Chem, 400(7):811-812.

 

Müller SI1, Aschenbrenner I1,  Zacharias M*, Feige MJ*
An interspecies analysis reveals molecular construction principles of interleukin 27. [read]
J Mol Biol, 431(12):2383-2393.

 

Coelho JPL, Stahl M, Bloemeke N, Meighen-Berger K, Piedrafita Alvira C, Zhang ZR, Sieber SA, Feige MJ*
A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. [read]
Nat Commun, 10:672.

 

Müller SI, Friedl A, Aschenbrenner I, Esser-von Bieren J, Zacharias M, Devergne O*, Feige MJ*
A folding switch regulates interleukin 27 biogenesis and secretion of its alpha subunit as a cytokine. [read], [press release]
Proc Natl Acad Sci U S A, 116(5):1585-1590.

2018

Grötsch RK1, Angi A1, Mideksa YG, Wanzke C, Tena-Solsona M, Feige MJ, Rieger B, Boekhoven J*
Dissipative Self-Assembly of Photoluminescent Silicon Nanocrystals. [read]
Angew Chem, 57(44):14608-14612.

Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B*
hIAPP forms toxic oligomers in plasma. [read]
Chem Commun, 54(43):5426-5429.

2017

Reitberger S, Haimerl P, Aschenbrenner I, Esser-von Bieren J, Feige MJ*
Assembly-induced folding regulates interleukin 12 biogenesis and secretion. [read]
J Biol Chem, 292(19):8073-8081.

2016

Behnke J1, Mann M1, Scruggs FL, Feige MJ*, Hendershot LM*
Members of the Hsp70 family recognize distinct types of sequences to execute ER quality control. [read]
Mol Cell, 63(5):739-752.

2015

Feige MJ*, Behnke J, Mittag T, Hendershot LM*
Dimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chains. [read]
J Biol Chem, 290(44):26821-31.

Behnke J1, Feige M1, Hendershot LM*
BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions. [read]
J Mol Biol, 427(7):1589-1608.

2014

Feige MJ*, Buchner J*
Principles and engineering of antibody folding and assembly. [read]
Biochim Biophys Acta, 1844(11):2024-31.

Otero JH1, Lizák B1, Feige MJ, Hendershot LM*
Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum. [read]
J Biol Chem, 289(40):27504-12.

Feige MJ1,*, Gräwert MA1,, Marcinowski M1,, Hennig J1,, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J.
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. [read]
Proc Natl Acad Sci U S A, 111(22):8155-60.

2013

Feige MJ*, Hendershot LM*
Quality control of integral membrane proteins by assembly-dependent membrane integration. [read]
Mol Cell, 51(3):297-309.

Hendershot LM*, Feige MJ*, Buchner J*
Acidification activates ERp44--a molecular litmus test for protein assembly. [read]
Mol Cell, 50(6):779-81.

Marcinowski M, Rosam M, Seitz C, Elferich J, Behnke J, Bello C, Feige MJ, Becker CF, Antes I*, Buchner J*
Conformational selection in substrate recognition by Hsp70 chaperones. [read]
J Mol Biol, 425(3):466-74.

2012

Howes J, Shimizu Y, Feige MJ, Hendershot LM*
C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome. [read]
J Biol Chem, 287(11):8552-60.

 

2011

Feige MJ, Hendershot LM*
Disulfide bonds in ER protein folding and homeostasis. [read]
Curr Opin Cell Biol, 23(2):167-75.

Marcinowski M1, Höller M1, Feige MJ, Baerend D, Lamb DC*, Buchner J*
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. [read]
Nat Struct Mol Biol, 18(2):150-8.

2010

Bertz M1, Chen J1, Feige MJ, Franzmann TM, Buchner J*, Rief M*
Structural and mechanical hierarchies in the alpha-crystallin domain dimer of the hyperthermophilic small heat shock protein Hsp16.5. [read]
J Mol Biol, 400(5):1046-56.

Feige MJ1, Simpson ER1, Herold EM1, Bepperling A, Heger K, Buchner J*
Dissecting the alternatively folded state of the antibody Fab fragment. [read]
J Mol Biol, 399(5):719-30.

Chen J, Feige MJ, Franzmann TM, Bepperling A, Buchner J*
Regions outside the alpha-crystallin domain of the small heat shock protein Hsp26 are required for its dimerization. [read]
J Mol Biol, 398(1):122-31.

Feige MJ, Hendershot LM*, Buchner J*
How antibodies fold. [read]
TIBS, 35(4):189-98.

2009

Feige MJ1, Nath S1, Catharino SR, Weinfurtner D, Steinbacher S, Buchner J*
Structure of the murine unglycosylated IgG1 Fc fragment. [read]
J Mol Biol, 391(3):599-608.

Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J*
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. [read]
Mol Cell, 34(5):569-79.

2008

Feige MJ, Paci E*
Rate of loop formation in peptides: a simulation study. [read]
J Mol Biol 2008, 382(2):556-65.

Feige MJ1, Groscurth S1, Marcinowski M, Yew ZT, Truffault V, Paci E, Kessler H, Buchner J*
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. [read]
Proc Natl Acad Sci U S A, 105(36):13373-8.

2007

Feige MJ, Hagn F, Esser J, Kessler H, Buchner J*
Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain. [read]
J Mol Biol, 365(4):1232-44.

2004

Feige MJ, Walter S, Buchner J*
Folding mechanism of the CH2 antibody domain. [read]
J Mol Biol, 344(1):107-18.


Book Publications

2018

Feige MJ, Braakman I, Hendershot LM
Chapter 1.1: Disulfide bonds in protein folding and stability. [read]
RSC Publishing, in Oxidative Folding of Proteins (edited bei MJ Feige).

2008

Feige MJ, Buchner J
Chapter 2: Oxidative Folding of Proteins in vitro. [read]
RSC Publishing, in Oxidative Folding of Peptides and Proteins (edited by L Moroder and J Buchner).